Lydia West, Nathaniel Curtis and David Carlyle play the characters of Jill Baxter, Ash Mukherjee and Gregory Finch respectively. Together they form the ensemble which the show focuses on most. Other actors cast were Keeley Hawes, Shaun Dooley, Tracy Ann Oberman, Neil Patrick Harris and Stephen Fry. It premiered in the United Kingdom on Channel 4 on 22 January 2021. The show's subject matter of HIV and AIDS was difficult to sell to broadcasters. BBC One and ITV declined to develop the series and Channel 4 only took it on after their commissioning editor of drama, Lee Mason, fought for it. The show was then shortened from eight planned episodes to five and principal photography commenced in Manchester on 7 October 2019. Despite its London setting, It's a Sin was filmed mainly in Manchester with other locations used in Liverpool, Bolton, Eccles, Bangor, and Rhos-on-Sea. The series was executive produced by Davies and Nicola Shindler. Phil Collinson was hired as the show's producer and Peter Hoar as executive producer and director.
The show received critical acclaim for its emotional scenes, writing and depiction of AIDS the cast performances were also met with widely positive reviews. All episodes were released to the broadcaster's online streaming service All 4. After a few weeks, it was viewed in its entirety more than 6.5 million times making it the most binge-watched show to stream on the platform.
